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Cytochrome P450 Inhibitors: A Comprehensive List - ClinCalc Reference
Cytochrome P450 (CYP450) inhibitors decrease the activity of the CYP450 isoenzymes responsible for the metabolism of several drugs, which can increase drug levels in the body and lead to adverse effects. This is a two-page list of drugs acting as CYP inhibitors.
Site: https://clincalc.com/DrugStats/Drugs/CYP450inhibitors
Cytochrome P450 Inhibitors | VEGA Test
MDPI: Cytochrome P450 Inhibitors. What is a Cytochrome P450 Inhibitor? A cytochrome P450 inhibitor is a substance that inhibits the activity of cytochrome P450 enzymes. Cytochrome P450 enzymes are found in the liver and are responsible for metabolizing drugs and other chemicals.
Site: https://vega.sanfordhealth.org/cytochrome-p450-inhibitors
CYP450 Drug Interaction Table - Inhibitor and Inducer Effects
CYP450 Drug Interaction Table - Find drug interactions that may alter the metabolism of another drug and cause potential adverse effects. Covers drugs with strong, moderate, and weak inhibition or induction of CYP450 isoenzymes. Includes comedications, supplements, food, and more.
Site: https://reference.medscape.com/drug-interactionchecker/interactions/inhibitor-inducer?name1=phenytoin
CYP450 Inhibitors: Mechanisms and Clinical Implications
MDPI: CYP450 Inhibitors: Mechanisms and Clinical Implications. Abstract: Cytochrome P450 (CYP) enzymes are a superfamily of monooxygenases that play a crucial role in the metabolism of endogenous compounds and xenobiotics, including drugs. CYP450 enzymes are found in the liver, gastrointestinal …
Site: https://www.mdpi.com/1422-0067/21/6/700
CYP450 Inhibitors in the Management of Drug Interactions
Abstract. Cytochrome P450 (CYP450) enzymes play a major role in the metabolism of drugs. The inhibition of CYP450 enzymes by coadministered drugs can result in drug interactions and increased risk for adverse events. This review summarizes the mechanisms of CYP450 inhibition and discusses ...
Site: https://academic.oup.com/ijnp/article/24/2/330/5737286
P450 Inhibitors | Medicine | NEJM
NEJM: Mechanism-Based Inactivation of Cytochromes P450: A Review. Abstract: Metabolic interactions involving cytochrome P450 (CYP) inhibition are a major cause of drug-induced toxicity and therapeutic failure. Mechanism-based inactivation refers to a process in which a chemical ...
Site: https://www.nejm.org/doi/full/10.1056/nejmra1508012
Inhibition of Cytochrome P450 (CYP) Enzymes - an Overview
Inhibition of Cytochrome P450 (CYP) Enzymes - an Overview. CYP enzymes are responsible for the metabolism of a wide variety of xenobiotics, including drugs and environmental pollutants. Inhibition of CYP enzymes can lead to increased drug levels and/or toxicity, and can also affect the metabolism of ...
Site: https://www.sciencedirect.com/science/article/pii/B9780128023375001032
Cytochrome P450 Drug Interaction Table - University of Washington
Cytochrome P450 (CYP) enzymes are drug-metabolizing enzymes that are responsible for many drug interactions. Inhibitors, Inducers, and Substrates of Cytochrome P450 Isoenzymes. The following table shows the common inhibitors, inducers, and substrates of the various CYP isoenzymes.
Site: http://www.pharm.washington.edu/labs/cytochrome450/druginteractionstable.php
CYP450 Inhibitor Drugs - StatPearls - NCBI Bookshelf
CYP450 Inhibitor Drugs. Author: Anas A. Alshehri; Affiliations: College of Medicine in Aljouf, Sakaka, Saudi Arabia; Last Update: November 30, 2022. Objectives. Upon completion of this activity, the reader will be able to describe the different types of CYP450 inhibitors.
Site: https://www.ncbi.nlm.nih.gov/books/NBK551573/
P450 Interactions - Drugs and Supplements - Mayo Clinic
P450 Interactions - Drugs and Supplements. Explained by Andrew M. Schafer, PharmD. ... P-glycoprotein, a membrane protein, is also involved in drug interactions. Foods that inhibit P-glycoprotein can increase blood levels of certain P-glycoprotein-transported drugs.
Site: https://www.mayoclinic.org/diseases-conditions/drug-interactions/in-depth/drug-interactions/art-20045700